The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Wang DY, Forslund C, Persson U, Wiholm BE

Drug-attributed anaphylaxis.

Pharmacoepidemiology and drug safety. 1998;7(4):269-74

Hernández D, de Rojas F, Martínez Escribano C, Arriaga F, Cuellar J, Molins J, Barber L

Fatal dextran-induced allergic anaphylaxis.

Allergy. 2002;57(9):862

Perlitz Y, Oettinger M, Karam K, Lipshitz B, Simon K

Anaphylactic shock during hysteroscopy using Hyskon solution: case report and review of adverse reactions and their treatment.

Gynecologic and obstetric investigation. 1996;41(1):67-9

Chan YF, Huang ST, Chan HC, Tan PP

[Intraoperative anaphylactic shock--report of two cases].

Ma zui xue za zhi = Anaesthesiologica Sinica. 1989;27(4):389-93

Ljungström KG, Revenäs B, Smedegård G, Hedin H, Richter W, Saldeen T

Histopathological lung changes in immune complex mediated anaphylactic shock in humans elicited by dextran.

Forensic science international. 1988;38(3-4):251-8

Fanous LH, Gray A, Felmingham J

Severe anaphylactoid reactions to dextran 70.

British medical journal. 1977;2(6096):1189-90