The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Obergassel L, Carlsson J, Tebbe U

[ACE inhibitor-associated interstitial lung infiltrates].

Deutsche medizinische Wochenschrift (1946) 1995 Sep 22;120;1273-7 — 1995 Sep 22 — 1273-7

Schatz PL, Mesologites D, Hyun J, Smith GJ, Lahiri B

Captopril-induced hypersensitivity lung disease. An immune-complex-mediated phenomenon.

Chest 1989 Mar;95;685-7 — 1989 Mar — 685-7

Kidney JC, O'Halloran DJ, FitzGerald MX

Captopril and lymphocytic alveolitis.

BMJ (Clinical research ed.) 1989 Oct 14;299;981 — 1989 Oct 14 — 981