The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Makatsori M, Calderon MA

Anaphylaxis: still a ghost behind allergen immunotherapy.

Current opinion in allergy and clinical immunology. 2014;14(4):316-22

Renaudin JM, Beaudouin E, Ponvert C, Demoly P, Moneret-Vautrin DA

Severe drug-induced anaphylaxis: analysis of 333 cases recorded by the Allergy Vigilance Network from 2002 to 2010.

Allergy. 2013;68(7):929-37

Viswanathan RK, Busse WW

Allergen immunotherapy in allergic respiratory diseases: from mechanisms to meta-analyses.

Chest. 2012;141(5):1303-1314

Reid MJ, Lockey RF, Turkeltaub PC, Platts-Mills TA

Survey of fatalities from skin testing and immunotherapy 1985-1989.

The Journal of allergy and clinical immunology. 1993;92(1 Pt 1):6-15