The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pleural/pericardial effusion, ANA positive (DI lupus)
Publications
Simvastatin-induced lupus-like syndrome.
Tennessee medicine : journal of the Tennessee Medical Association 2000 Jan;93;21-2 — 2000 Jan — 21-2
Simvastatin-induced lupus erythematosus.
Southern medical journal 1998 Sep;91;873-4 — 1998 Sep — 873-4