The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.g

Pulmonary fibrosis

Publications

Kalaycio M, Pohlman B, Kuczkowski E, Rybicki L, Andresen S, Sobecks R, Bolwell B

High-dose busulfan and the risk of pulmonary mortality after autologous stem cell transplant.

Clinical transplantation 2006 Nov-Dec;20;783-7 — 2006 Nov-Dec — 783-7

Lohani S, O'Driscoll BR, Woodcock AA

25-year study of lung fibrosis following carmustine therapy for brain tumor in childhood.

Chest 2004 Sep;126;1007 — 2004 Sep — 1007

OLINER H, SCHWARTZ R, RUBIO F, DAMESHEK W

Interstitial pulmonary fibrosis following busulfan therapy.

The American journal of medicine 1961 Jul;31;134-9 — 1961 Jul — 134-9

Selker RG, Jacobs SA, Moore PB, Wald M, Fisher ER, Cohen M, Bellot P

1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced pulmonary fibrosis.

Neurosurgery 1980 Dec;7;560-5 — 1980 Dec — 560-5

Podoll LN, Winkler SS

Busulfan lung. Report of two cases and review of the literature.

The American journal of roentgenology, radium therapy, and nuclear medicine 1974 Jan;120;151-6 — 1974 Jan — 151-6

Massin F, Fur A, Reybet-Degat O, Camus P, Jeannin L

[Busulfan-induced pneumopathy].

Revue des maladies respiratoires 1987;4;3-10 — 1987 — 3-10

Soble AR, Perry H

Fatal radiation pneumonia following subclinical busulfin injury.

AJR. American journal of roentgenology 1977 Jan;128;15-8 — 1977 Jan — 15-8

Pearl M

Busulfan lung.

American journal of diseases of children (1960) 1977 Jun;131;650-2 — 1977 Jun — 650-2