The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLI.e

ARDS - Acute lung injury

See also http://www.fda.gov/downloads/drugs/drugsafety/drugsafetynewsletter/ucm109178.pdf

Publications

Virzì F, Giacopelli G, Tutone P, Profera L, Giarratano A, Raineri SM, Tomasello S, Accurso G

Acute eosinophilic pneumonia associated with mefloquine prophylaxis: A case report.

Respiratory medicine case reports 2025;56;102238 — 2025 — 102238

Udry E, Bailly F, Dusmet M, Schnyder P, Lemoine R, Fitting JW

Pulmonary toxicity with mefloquine.

The European respiratory journal 2001 Nov;18;890-2 — 2001 Nov — 890-2