The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.e

Autoimmunity-Autoimmune conditions (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)

Publications

Mili? R, Plavec G, Tufegdzi? I, Tomi? I, Sarac S, Loncarevi? O

Nitrofurantoin-induced immune-mediated lung and liver disease.

Vojnosanitetski pregled 2012 Jun;69;536-40 — 2012 Jun — 536-40

Mendez JL, Nadrous HF, Hartman TE, Ryu JH

Chronic nitrofurantoin-induced lung disease.

Mayo Clinic proceedings 2005 Oct;80;1298-302 — 2005 Oct — 1298-302