The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

V.c

Pleural thickening - Fibrothorax

Publications

Andersohn F, Garbe E

Cardiac and noncardiac fibrotic reactions caused by ergot-and nonergot-derived dopamine agonists.

Movement disorders : official journal of the Movement Disorder Society. 2009;24(1):129-33

Müller T, Fritze J

Fibrosis associated with dopamine agonist therapy in Parkinson's disease.

Clinical neuropharmacology. 2003;26(3):109-11

Champagne S, Coste E, Peyrière H, Nigond J, Mania E, Pons M, Hillaire-Buys D, Balmes P, Blayac JP, Davy JM

Chronic constrictive pericarditis induced by long-term bromocriptine therapy: report of two cases.

The Annals of pharmacotherapy. 1999;33(10):1050-4

Comet R, Domingo C, Such JJ, Ribera G, Sans J, Marín A

Pleuropulmonary disease as a side-effect of treatment with bromocriptine.

Respiratory medicine. 1998;92(9):1172-4

Hillerdal G, Lee J, Blomkvist A, Rask-Andersen A, Uddenfeldt M, Koyi H, Rasmussen E

Pleural disease during treatment with bromocriptine in patients previously exposed to asbestos.

The European respiratory journal. 1997;10(12):2711-5

Klaassen RJ, Troost RJ, Verhoeven GT, Krepel HP, van der Lely AJ

Suggestive evidence for bromocriptine-induced pleurisy.

The Netherlands journal of medicine. 1996;48(6):232-6

Vergeret J, Barat M, Taytard A, Bellvert P, Domblides P, Douvier JJ, Fréour P

[Pleuropulmonary fibrosis and bromocriptine].

La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris. 1984;60(11):741-4

Besser GM, Wass JA

Pleuropulmonary shadows on bromocriptine.

Lancet (London, England). 1981;1(8215):323

Tornling G, Unge G, Axelsson G, Noring L, Granerus AK

Pleuropulmonary reactions in patients on bromocriptine treatment.

European journal of respiratory diseases. 1986;68(1):35-8

Kinnunen E, Viljanen A

Pleuropulmonary involvement during bromocriptine treatment.

Chest. 1988;94(5):1034-6

McElvaney NG, Wilcox PG, Churg A, Fleetham JA

Pleuropulmonary disease during bromocriptine treatment of Parkinson's disease.

Archives of internal medicine. 1988;148(10):2231-6

Melmed S, Braunstein GD

Bromocriptine and pleuropulmonary disease.

Archives of internal medicine. 1989;149(2):258-9