The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.j

Myopathy-Myositis-Polymyositis (see also under Xba)

Autoantibodies can be present, notably the anti-Jo1

Publications

Kunwar S, Parekh JD, Chilukuri RS, Andukuri VA

Necrotizing Autoimmune myopathy: A case report on statin induced rhabdomyolysis requiring immunosuppressive therapy.

Drug discoveries & therapeutics. 2018;12(5):315-317

Borges IBP, Silva MG, Misse RG, Shinjo SK

Lipid-lowering agent-triggered dermatomyositis and polymyositis: a case series and literature review.

Rheumatology international. 2018;38(2):293-301

Mammen AL

Statin-Associated Autoimmune Myopathy.

The New England journal of medicine. 2016;374(7):664-9

Meira Dias O, Guedes Baldi B, Nathan Costa A, Katsuyuki Shinjo S, Miossi R, Adib Kairalla R

Interstitial lung disease with statin-associated necrotizing autoimmune myopathy responding to rituximab.

Archivos de bronconeumologia. 2016;52(7):395-7

Grable-Esposito P, Katzberg HD, Greenberg SA, Srinivasan J, Katz J, Amato AA

Immune-mediated necrotizing myopathy associated with statins.

Muscle & nerve. 2010;41(2):185-90

Sailler L, Pereira C, Bagheri A, Uro-Coste E, Roussel B, Adoue D, Fournie B, Laroche M, Zabraniecki L, Cintas P, Arlet P, Lapeyre-Mestre M, Montastruc JL

Increased exposure to statins in patients developing chronic muscle diseases: a 2-year retrospective study.

Annals of the rheumatic diseases. 2008;67(5):614-9

Takagi A, Shiio Y

[Pravastatin-associated polymyositis, a case report].

Rinsho shinkeigaku = Clinical neurology. 2004;44(1):25-7

Fauchais AL, Iba Ba J, Maurage P, Kyndt X, Bataille D, Hachulla E, Parent D, Queyrel V, Lambert M, Michon Pasturel U, Hatron PY, Vanhille P, Devulder B

[Polymyositis induced or associated with lipid-lowering drugs: five cases].

La Revue de medecine interne. 2004;25(4):294-8

Riesco-Eizaguirre G, Arpa-Gutiérrez FJ, Gutiérrez M, Toribio E

[Severe polymyositis with simvastatin use].

Revista de neurologia. 2003;37(10):934-6

Forestier F, Breton Y, Bonnet E, Janvier G

Severe rhabdomyolysis after laparoscopic surgery for adenocarcinoma of the rectum in two patients treated with statins.

Anesthesiology. 2002;97(4):1019-21