The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Madani H, Sadiki EO, Bouziane M, Amaarouch S, Madani M, Khatouf M

[Anaphylaxis to protamine during cardiovascular surgery].

Annales pharmaceutiques francaises. 2014;72(3):143-5

Webb LM, Lieberman P

Anaphylaxis: a review of 601 cases.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2006;97(1):39-43

Levy JH

Antibody formation after drug administration during cardiac surgery: parameters for aprotinin use.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 1993;12(1 Pt 1):S26-33

Weiss ME, Nyhan D, Peng ZK, Horrow JC, Lowenstein E, Hirshman C, Adkinson NF Jr

Association of protamine IgE and IgG antibodies with life-threatening reactions to intravenous protamine.

The New England journal of medicine. 1989;320(14):886-92

Gupta SK, Veith FJ, Ascer E, Wengerter KR, Franco C, Amar D, el-Gaweet ES, Gupta A

Anaphylactoid reactions to protamine: an often lethal complication in insulin-dependent diabetic patients undergoing vascular surgery.

Journal of vascular surgery. 1989;9(2):342-50