The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IX.d

Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

Publications

Wunsch H, Moitra VK, Patel M, Dzierba AL

Polymyxin use associated with respiratory arrest.

Chest. 2012;141(2):515-517

Pohlmann G

Respiratory arrest associated with intravenous administration of polymyxin B sulfate.

JAMA. 1966;196(2):181-3

Lee C, Chen D, Nagel EL

Neuromuscular block by antibiotics: polymyxin B.

Anesthesia and analgesia. 1977;56(3):373-7