The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

L.c

Pleuritic chest pain

Publications

Zhang D, Ding Z, Qian J, Xie X, Wang Y

Two rare cases of methotrexate-induced pneumonitis and pleurisy in patients with gestational trophoblastic neoplasms.

European journal of gynaecological oncology 2008;29;390-2 — 2008 — 390-2

Sharma S, Jagdev S, Coleman RE, Hancock BW, Lorigan PC

Serosal complications of single-agent low-dose methotrexate used in gestational trophoblastic diseases: first reported case of methotrexate-induced peritonitis.

British journal of cancer 1999 Nov;81;1037-41 — 1999 Nov — 1037-41

Urban C, Nirenberg A, Caparros B, Anac S, Cacavio A, Rosen G

Chemical pleuritis as the cause of acute chest pain following high-dose methotrexate treatment.

Cancer 1983 Jan 01;51;34-7 — 1983 Jan 01 — 34-7

Walden PA, Mitchell-Weggs PF, Coppin C, Dent J, Bagshawe KD

Pleurisy and methotrexate treatment.

British medical journal 1977 Oct 01;2;867 — 1977 Oct 01 — 867