The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIV.a

Angioedema (may cause UAO, asphyxia and death)

Publications

Freeman AM, Dasgupta B

Angio-neurotic oedema associated with methotrexate treatment in rheumatoid arthritis.

Rheumatology (Oxford, England) 1999 Sep;38;908 — 1999 Sep — 908

Alkins SA, Byrd JC, Morgan SK, Ward FT, Weiss RB

Anaphylactoid reactions to methotrexate.

Cancer 1996 May 15;77;2123-6 — 1996 May 15 — 2123-6