The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Publications

Beaudry C, Laplante L

Severe allergic pneumonitis from hydrochlorothiazide.

Annals of internal medicine 1973 Feb;78;251-3 — 1973 Feb — 251-3

Biron P, Dessureault J, Napke E

Acute allergic interstitial pneumonitis induced by hydrochlorothiazide.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1991 Jul 01;145;28-34 — 1991 Jul 01 — 28-34