The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLI.e

ARDS - Acute lung injury

Publications

Kudoh S, Kato H, Nishiwaki Y, Fukuoka M, Nakata K, Ichinose Y, Tsuboi M, Yokota S, Nakagawa K, Suga M, , Jiang H, Itoh Y, Armour A, Watkins C, Higenbottam T, Nyberg F

Interstitial lung disease in Japanese patients with lung cancer: a cohort and nested case-control study.

American journal of respiratory and critical care medicine 2008 Jun 15;177;1348-57 — 2008 Jun 15 — 1348-57

Endo M, Johkoh T, Kimura K, Yamamoto N

Imaging of gefitinib-related interstitial lung disease: multi-institutional analysis by the West Japan Thoracic Oncology Group.

Lung cancer (Amsterdam, Netherlands) 2006 May;52;135-40 — 2006 May — 135-40

Ieki R, Saitoh E, Shibuya M

Acute lung injury as a possible adverse drug reaction related to gefitinib.

The European respiratory journal 2003 Jul;22;179-81 — 2003 Jul — 179-81