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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

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Chylothorax

See also: Tsiouprou, I., et al., Dasatinib-induced chylothorax in a patient with chronic myeloid leukemia. Pneumon, 2018; 31: 183-186

Publications

Ng IK, Ruparel M, Chan EH, Khoo KL

Drug-induced chylothorax as a rare pleural complication in dasatinib therapy for chronic myeloid leukaemia.

The journal of the Royal College of Physicians of Edinburgh. 2024;54(1):44-47

Liu Q, Fu J, Zhang A

Dasatinib-associated chylothorax in a pediatric patient with chronic myeloid leukemia: a case report and literature review.

Translational cancer research. 2023;12(1):194-200

Hsu CC, Hsu JF, Wu KL

Dasatinib-induced chylothorax in a patient with chronic myeloid leukaemia: a case report and literature review.

Respirology case reports. 2021;9(6):e00753

Chen B, Wu Z, Wang Q, Li W, Cheng D

Dasatinib-induced chylothorax: report of a case and review of the literature.

Investigational new drugs. 2020;38(5):1627-1632

Hickman K, Diaz E, Graham R, Adams R, Ngwube A

Dasatinib-induced Chylothorax in Chronic Myelogenous Leukemia in Pediatric Patient: Report of a Case and Review of Literature.

Journal of pediatric hematology/oncology. 2020;42(7):e665-e667

Baloch ZQ, Abbas SA, Bhatti H, Braver Y, Ali SK

Dasatinib-induced chylothorax in chronic myeloid leukemia.

Proceedings (Baylor University. Medical Center). 2017;30(1):71-73

Goldblatt M, Huggins JT, Doelken P, Gurung P, Sahn SA

Dasatinib-induced pleural effusions: a lymphatic network disorder?

The American journal of the medical sciences. 2009;338(5):414-7