The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Potolidis E, Mandros C

Carboplatin-induced hypersensitivity reaction.

Case reports in oncology. 2012;5(1):141-2

Winkeljohn D, Polovich M

Carboplatin hypersensitivity reactions.

Clinical journal of oncology nursing. 2006;10(5):595-8

Moreno-Ancillo A, Domínguez-Noche C, Gil-Adrados AC, Cosmes PM, Duarte I, Mateos Y

Anaphylactoid reaction to carboplatin: successful "desensitization".

Allergologia et immunopathologia. 2003;31(6):342-4

Markman M, Zanotti K, Kulp B, Peterson G, Markman M

Relationship between a history of systemic allergic reactions and risk of subsequent carboplatin hypersensitivity.

Gynecologic oncology. 2003;89(3):514-6

Windom HH, McGuire WP 3rd, Hamilton RG, Adkinson NF Jr

Anaphylaxis to carboplatin--a new platinum chemotherapeutic agent.

The Journal of allergy and clinical immunology. 1992;90(4 Pt 1):681-3