The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIX.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Oulego-Erroz I, Maneiro-Freire M, Bouzón-Alejandro M, Vázquez-Donsión M, Couselo JM

Anaphylactoid reaction to high-dose methotrexate and successful desensitization.

Pediatric blood & cancer 2010 Sep;55;557-9 — 2010 Sep — 557-9

Straka M, Zeringue E, Goldman M

A rare drug reaction to methotrexate after treatment for ectopic pregnancy.

Obstetrics and gynecology 2004 May;103;1047-8 — 2004 May — 1047-8

Alkins SA, Byrd JC, Morgan SK, Ward FT, Weiss RB

Anaphylactoid reactions to methotrexate.

Cancer 1996 May 15;77;2123-6 — 1996 May 15 — 2123-6

Goldberg NH, Romolo JL, Austin EH, Drake J, Rosenberg SA

Anaphylactoid type reactions in two patients receiving high dose intravenous methotrexate.

Cancer 1978 Jan;41;52-5 — 1978 Jan — 52-5