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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

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The immune reconstitution syndrome (IRCS)

Publications

Offner M, Perpoint T, Chidiac C, Ferry T

Large liquefaction of lymph nodes during tuberculosis-associated immune reconstitution inflammatory syndrome in an HIV-infected woman.

BMJ case reports. 2012;2012

Sovaila S, de Raigniac A, Picard C, Taulera O, Lascoux-Combe C, Sereni D, Bourgarit A

Acute microbiologically negative hypoxic interstitial pneumonia on HAART: Immune Reconstitution Inflammatory Syndrome unmasking Pneumocystis jiroveci infection with an atypical presentation.

Journal of medicine and life. 2012;5(2):189-91

Calligaro G, Meintjes G, Mendelson M

Pulmonary manifestations of the immune reconstitution inflammatory syndrome.

Current opinion in pulmonary medicine. 2011;17(3):180-8

Schluger NW, Perez D, Liu YM

Reconstitution of immune responses to tuberculosis in patients with HIV infection who receive antiretroviral therapy.

Chest. 2002;122(2):597-602

Shelburne SA 3rd, Hamill RJ, Rodriguez-Barradas MC, Greenberg SB, Atmar RL, Musher DW, Gathe JC Jr, Visnegarwala F, Trautner BW

Immune reconstitution inflammatory syndrome: emergence of a unique syndrome during highly active antiretroviral therapy.

Medicine. 2002;81(3):213-27