The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLV.i

Pleuritis (can cause chest pain)

Publications

Jones SE, Moore M, Blank N, Castellino RA

Hypersensitivity to procarbazine (Matulane) manifested by fever and pleuropulmonary reaction.

Cancer 1972 Feb;29;498-500 — 1972 Feb — 498-500

Ecker MD, Jay B, Keohane MF

Procarbazine lung.

AJR. American journal of roentgenology 1978 Sep;131;527-8 — 1978 Sep — 527-8