The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

V.i

Pleuritis (can cause chest pain)

Publications

Hardak E, Berger G, Krivoy N, Solomonov A, Yigla M

Nitrofurantoin pulmonary toxicity: neglected threat.

Current drug safety. 2010;5(2):125-8

Williams EM, Triller DM

Recurrent acute nitrofurantoin-induced pulmonary toxicity.

Pharmacotherapy. 2006;26(5):713-8

ROBINSON BR

PLEUROPULMONARY REACTION TO NITROFURANTOIN.

JAMA. 1964;189:239-40

Tempelaar AF

[Acute allergic pulmonary reaction following use of nitrofurantoin].

Nederlands tijdschrift voor geneeskunde. 1980;124(19):751-5

Holmberg L, Boman G

Pulmonary reactions to nitrofurantoin. 447 cases reported to the Swedish Adverse Drug Reaction Committee 1966-1976.

European journal of respiratory diseases. 1981;62(3):180-9

Strauss WG, Griffin LM

Nitrofurantoin pneumonia.

JAMA. 1967;199(10):765-6

Murray MJ, Kronenberg R

Pulmonary reactions simulating cardiac pulmonary edema caused by nitrofurantoin.

The New England journal of medicine. 1965;273(22):1185-7

Allen RW, Holt AH, Brown MG

Acute pulmonary sensitivity to nitrofurantoin.

The American journal of roentgenology, radium therapy, and nuclear medicine. 1968;104(4):784-6

Hailey FJ, Glascock HW Jr, Hewitt WF

Pleuropneumonic reactions to nitrofurantoin.

The New England journal of medicine. 1969;281(20):1087-90

Jick SS, Jick H, Walker AM, Hunter JR

Hospitalizations for pulmonary reactions following nitrofurantoin use.

Chest. 1989;96(3):512-5