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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Yegin ZA, Aki S, Sucak G, Yagci M

Cytarabine induced noncardiogenic pulmonary edema in a case of acute lymphoblastic leukemia.

International journal of laboratory hematology. 2007;29(6):482-3

Kirchner J, Boehme A, Hüttmann C, Jacobi V

[Pulmonary complications of induction therapy in acute myeloid leukemia in adults. Findings in chest x-rays and computer tomography].

Aktuelle Radiologie. 1998;8(2):87-94

Chiche D, Pico JL, Bernaudin JF, Chouaib S, Wollman E, Arnoux A, Denizot Y, Nitenberg G

Pulmonary edema and shock after high-dose aracytine-C for lymphoma; possible role of TNF-alpha and PAF.

European cytokine network. 1993;4(2):147-51

Shearer P, Katz J, Bozeman P, Jenkins J, Laver J, Krance R, Hurwitz C, Mahmoud H, Mirro J

Pulmonary insufficiency complicating therapy with high dose cytosine arabinoside in five pediatric patients with relapsed acute myelogenous leukemia.

Cancer. 1994;74(7):1953-8

Haupt HM, Hutchins GM, Moore GW

Ara-C lung: noncardiogenic pulmonary edema complicating cytosine arabinoside therapy of leukemia.

The American journal of medicine. 1981;70(2):256-61

Tham RT, Peters WG, de Bruïne FT, Willemze R

Pulmonary complications of cytosine-arabinoside therapy: radiographic findings.

AJR. American journal of roentgenology. 1987;149(1):23-7

Jehn U, Göldel N, Rienmüller R, Wilmanns W

Non-cardiogenic pulmonary edema complicating intermediate and high-dose Ara C treatment for relapsed acute leukemia.

Medical oncology and tumor pharmacotherapy. 1988;5(1):41-7

Spriggs DR, Robbins G, Arthur K, Mayer RJ, Kufe D

Prolonged high dose ARA-C infusions in acute leukemia.

Leukemia. 1988;2(5):304-6

Andersson BS, Luna MA, Yee C, Hui KK, Keating MJ, McCredie KB

Fatal pulmonary failure complicating high-dose cytosine arabinoside therapy in acute leukemia.

Cancer. 1990;65(5):1079-84