The Drug-Induced Respiratory Disease Website and App

Cytosine arabinoside - Aracytine - Cytarabine - Ara-C

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLI.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Yegin ZA, Aki S, Sucak G, Yagci M

Cytarabine induced noncardiogenic pulmonary edema in a case of acute lymphoblastic leukemia.

International journal of laboratory hematology 2007 Dec;29;482-3 — 2007 Dec — 482-3

Kirchner J, Boehme A, Hüttmann C, Jacobi V

[Pulmonary complications of induction therapy in acute myeloid leukemia in adults. Findings in chest x-rays and computer tomography].

Aktuelle Radiologie 1998 Mar;8;87-94 — 1998 Mar — 87-94

Chiche D, Pico JL, Bernaudin JF, Chouaib S, Wollman E, Arnoux A, Denizot Y, Nitenberg G

Pulmonary edema and shock after high-dose aracytine-C for lymphoma; possible role of TNF-alpha and PAF.

European cytokine network 1993 Mar-Apr;4;147-51 — 1993 Mar-Apr — 147-51

Shearer P, Katz J, Bozeman P, Jenkins J, Laver J, Krance R, Hurwitz C, Mahmoud H, Mirro J

Pulmonary insufficiency complicating therapy with high dose cytosine arabinoside in five pediatric patients with relapsed acute myelogenous leukemia.

Cancer 1994 Oct 01;74;1953-8 — 1994 Oct 01 — 1953-8

Haupt HM, Hutchins GM, Moore GW

Ara-C lung: noncardiogenic pulmonary edema complicating cytosine arabinoside therapy of leukemia.

The American journal of medicine 1981 Feb;70;256-61 — 1981 Feb — 256-61

Tham RT, Peters WG, de Bruïne FT, Willemze R

Pulmonary complications of cytosine-arabinoside therapy: radiographic findings.

AJR. American journal of roentgenology 1987 Jul;149;23-7 — 1987 Jul — 23-7

Jehn U, Göldel N, Rienmüller R, Wilmanns W

Non-cardiogenic pulmonary edema complicating intermediate and high-dose Ara C treatment for relapsed acute leukemia.

Medical oncology and tumor pharmacotherapy 1988;5;41-7 — 1988 — 41-7

Spriggs DR, Robbins G, Arthur K, Mayer RJ, Kufe D

Prolonged high dose ARA-C infusions in acute leukemia.

Leukemia 1988 May;2;304-6 — 1988 May — 304-6

Andersson BS, Luna MA, Yee C, Hui KK, Keating MJ, McCredie KB

Fatal pulmonary failure complicating high-dose cytosine arabinoside therapy in acute leukemia.

Cancer 1990 Mar 01;65;1079-84 — 1990 Mar 01 — 1079-84