The Drug-Induced Respiratory Disease Website and App

Neuromuscular blocking agents (NMBA-NMBD)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Pouessel G, Tacquard C, Tanno LK, Mertes PM, Lezmi G

Anaphylaxis mortality in the perioperative setting: Epidemiology, elicitors, risk factors and knowledge gaps.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2024 Jan;54;11-20 — 2024 Jan — 11-20

Gouel-Chéron A, Neukirch C, Aubier B, Montravers P, Nicaise P, Chollet-Martin S, Mertes PM, Aubier M, Longrois D

Anaphylactic bronchospasm during general anesthesia is not related to asthma.

Allergy 2015 Apr;70;453-6 — 2015 Apr — 453-6

Oh YJ, Lee HJ

Multiple cross-reactivity to several types of neuromuscular blocking agents in a patient with rocuronium anaphylaxis.

Korean journal of anesthesiology 2013 Nov;65;473-4 — 2013 Nov — 473-4

Renaudin JM, Beaudouin E, Ponvert C, Demoly P, Moneret-Vautrin DA

Severe drug-induced anaphylaxis: analysis of 333 cases recorded by the Allergy Vigilance Network from 2002 to 2010.

Allergy 2013 Jul;68;929-37 — 2013 Jul — 929-37

Peroni DG, Sansotta N, Bernardini R, Crisafulli G, Franceschini F, Caffarelli C, Boner AL

Muscle relaxants allergy.

International journal of immunopathology and pharmacology 2011 Jul-Sep;24;S35-46 — 2011 Jul-Sep — S35-46

Jang YH, Kim SG, Son YH, Park JM

Rocuronium bromide induced anaphylaxis in a child -A case report-.

Korean journal of anesthesiology 2010 Dec;59;411-5 — 2010 Dec — 411-5

Pumphrey RS, Stanworth SJ

The clinical spectrum of anaphylaxis in north-west England.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1996 Dec;26;1364-70 — 1996 Dec — 1364-70

Moss J

Muscle relaxants and histamine release.

Acta anaesthesiologica Scandinavica. Supplementum 1995;106;7-12 — 1995 — 7-12

Stoelting RK

Allergic reactions during anesthesia.

Anesthesia and analgesia 1983 Mar;62;341-56 — 1983 Mar — 341-56