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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Pouessel G, Tacquard C, Tanno LK, Mertes PM, Lezmi G

Anaphylaxis mortality in the perioperative setting: Epidemiology, elicitors, risk factors and knowledge gaps.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2024;54(1):11-20

Gouel-Chéron A, Neukirch C, Aubier B, Montravers P, Nicaise P, Chollet-Martin S, Mertes PM, Aubier M, Longrois D

Anaphylactic bronchospasm during general anesthesia is not related to asthma.

Allergy. 2015;70(4):453-6

Oh YJ, Lee HJ

Multiple cross-reactivity to several types of neuromuscular blocking agents in a patient with rocuronium anaphylaxis.

Korean journal of anesthesiology. 2013;65(5):473-4

Renaudin JM, Beaudouin E, Ponvert C, Demoly P, Moneret-Vautrin DA

Severe drug-induced anaphylaxis: analysis of 333 cases recorded by the Allergy Vigilance Network from 2002 to 2010.

Allergy. 2013;68(7):929-37

Peroni DG, Sansotta N, Bernardini R, Crisafulli G, Franceschini F, Caffarelli C, Boner AL

Muscle relaxants allergy.

International journal of immunopathology and pharmacology. 2011;24(3 Suppl):S35-46

Jang YH, Kim SG, Son YH, Park JM

Rocuronium bromide induced anaphylaxis in a child -A case report-.

Korean journal of anesthesiology. 2010;59(6):411-5

Pumphrey RS, Stanworth SJ

The clinical spectrum of anaphylaxis in north-west England.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 1996;26(12):1364-70

Moss J

Muscle relaxants and histamine release.

Acta anaesthesiologica Scandinavica. Supplementum. 1995;106:7-12

Stoelting RK

Allergic reactions during anesthesia.

Anesthesia and analgesia. 1983;62(3):341-56