The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Takemasa A

Clopidogrel-induced Eosinophilia and Hypercalcemia with Multiple Organ Lesions Including Eosinophilic Pneumonia.

Internal medicine (Tokyo, Japan). 2022;61(17):2559-2560

Yamada K, Asai K, Yanagimoto M, Sone R, Inazu S, Mizutani R, Kadotani H, Watanabe T, Tochino Y, Kawaguchi T

Clopidogrel-induced Eosinophilia with Hypercalcemia.

Internal medicine (Tokyo, Japan). 2022;61(17):2681-2685

Inagaki Y, Tachibana K, Inoue Y, Kasai T, Inoue Y

Severe clopidogrel-induced DRESS with eosinophilic pneumonia associated with Epstein-Barr virus reactivation.

Respirology case reports. 2020;8(3):e00541

Mizuno Y, Shimizu H, Yamashita M, Horie Y, Mizō A

[A case of clopidogrel-induced eosinophilic pneumonia].

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2011;49(11):838-42