The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Pouessel G, Tacquard C, Tanno LK, Mertes PM, Lezmi G

Anaphylaxis mortality in the perioperative setting: Epidemiology, elicitors, risk factors and knowledge gaps.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2024;54(1):11-20

Dhopeshwarkar N, Sheikh A, Doan R, Topaz M, Bates DW, Blumenthal KG, Zhou L

Drug-Induced Anaphylaxis Documented in Electronic Health Records.

The journal of allergy and clinical immunology. In practice. 2019;7(1):103-111

Koplin JJ, Martin PE, Allen KJ

An update on epidemiology of anaphylaxis in children and adults.

Current opinion in allergy and clinical immunology. 2011;11(5):492-6

Gruchalla RS, Pirmohamed M

Clinical practice. Antibiotic allergy.

The New England journal of medicine. 2006;354(6):601-9

Leone R, Conforti A, Venegoni M, Motola D, Moretti U, Meneghelli I, Cocci A, Sangiorgi Cellini G, Scotto S, Montanaro N, Velo G

Drug-induced anaphylaxis : case/non-case study based on an italian pharmacovigilance database.

Drug safety. 2005;28(6):547-56

MINOZZI A

[On the pathogenesis of hemorrhagic phenomena during anaphylactic shock from penicillin].

Minerva medica. 1959;50:3482-9

JAMES LP Jr, AUSTEN KF

FATAL SYSTEMIC ANAPHYLAXIS IN MAN.

The New England journal of medicine. 1964;270:597-603

SPAULDING WB

Dangers in the use of some potent drugs.

Canadian Medical Association journal. 1962;87(24):1275-81

ETTER RL, MERRYMAN G

Anaphylactic shock and death due to penicillin; report of a case.

Annals of allergy. 1954;12(4):453-4

CURPHEY JT

Fatal anaphylaxis in bronchial asthma following administration of penicillin; report of two cases with autopsy findings.

New York state journal of medicine. 1953;53(9):1107-10

International Collaborative Study of Severe Anaphylaxis

Risk of anaphylaxis in a hospital population in relation to the use of various drugs: an international study.

Pharmacoepidemiology and drug safety. 2003;12(3):195-202

Xi-Moy S, Thorvilson NK, Edmiston CE, Woehlck HJ

Anaphylaxis to penicillin on reperfusion during liver transplantation.

Anesthesiology. 2000;93(1):280-1

Dunn AB, Blomquist J, Khouzami V

Anaphylaxis in labor secondary to prophylaxis against group B Streptococcus. A case report.

The Journal of reproductive medicine. 1999;44(4):381-4

Cullen DJ

Severe anaphylactic reaction to penicillin during halothane anaesthesia. A case report.

British journal of anaesthesia. 1971;43(4):410-2