Pneumotox » Drug » COVID19 (SARS-CoV2) vaccination/vaccine

COVID19 (SARS-CoV2) vaccination/vaccine

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Last update : 19/02/2022

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1

I.b Pneumonitis (ILD)

1

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1

I.y Progression, acceleration or exacerbation of preexisting ILD/fibrosis

1

I.ad Radiation recall pneumonitis

1

I.ay Unilateral interstitial lung disease

1

II.b ARDS - Acute lung injury

1

II.d Pulmonary edema, cardiogenic

1

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1

III.m Coagulopathy

1

VI.a Pulmonary embolism - Venous thrombosis/thromboembolism

1

VI.b Pulmonary arterial hypertension

1

VI.ac Pulmonary infarction

1

IX.r Myasthenia gravis - Myasthenic-like syndrome

1

IX.y A flare or relapse of preexisting myasthenia gravis

1

IX.ab Guillain-Barré (or GB-like) syndrome (w/wo ARF)

1

X.b Antiphospholipid antibodies w/wo the APL syndrome

1

X.d Lupus - Lupus syndrome (see also Vd)

1

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

2

X.h Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

1

X.j Myopathy-Myositis-Polymyositis (see also under Xba)

1

X.m Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)

1

X.s Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

1

X.aj Polyarteritis nodosa-like condition

1

X.be A flare of preexisting immune-mediated systemic/rheumatic disease

1

X.bf Anti-Jo-1 syndrome

1

X.bg IgA vasculitis

1

X.bh Protracted, prolonged anaphylaxis

1

XI.b Chest pain (acute or subacute), lone or prominent

1

XII.a Left or biventricular dysfunction/failure

1

XII.c Pericardial effusion (w/wo tamponade)

1

XII.d Myocarditis (can be fulminant)

2

XII.e Takotsubo (stress) cardiomyopathy

1

XII.h Eosinophilic myocarditis

1

XII.k Constrictive pericarditis - Pericardial thickening

1

XII.l Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

1

XII.m Cardiac- cardiorespiratory/pulmonary arrest

1

XII.q Pericarditis (see also under XIIc)

1

XII.ai Cardiotoxicity

2

XII.bf Myopericarditis (see under XIIc/d/g)

1

XV.a Path: NSIP-cellular pattern (see also Ia, Ib)

1

XV.c Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

1

XVI.b Imaging: Ground-glass opacities (GGO) / shadowing

1

XVI.c Imaging: A mosaic pattern of attenuation

1

XVI.ay Imaging: Asymmetrical, predominantly unilateral involvement

1

XIX.a BAL: An excess proportion of lymphocytes

1

XIX.c BAL: An excess proportion of eosinophils

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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