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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
II.v
Hypoxemia w/wo ARF from hepatopulmonary syndrome
Last update :
01/01/1970
Causative drugs
1
Ado-trastuzumab emtansine
II.f
II - Pulmonary edema - Acute lung injury - ARDS
II.f - Hypoxemia, low oxygen saturation (may occur in isolation)
II.v
II - Pulmonary edema - Acute lung injury - ARDS
II.v - Hypoxemia w/wo ARF from hepatopulmonary syndrome
VI.b
VI - Pulmonary vasculopathies
VI.b - Pulmonary arterial hypertension
1
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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