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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Ado-trastuzumab emtansine

2

II.f Hypoxemia, low oxygen saturation (may occur in isolation)

1
Last update : 16/11/2024
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Hepatopulmonary syndrome associated with long-term use of ado-trastuzumab emtansine (T-DM1) for treatment of HER2-positive metastatic breast cancer - a case report and series.
Frontiers in oncology 2024;14;1434492 2024

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