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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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IV.aj

Airway hemorrhage on endoscopy

Last update : 01/01/1970
 

Causative drugs

1

Chlorine gas (dichlorine: Cl2)

I.af I - Interstitial/parenchymal lung disease
I.af - Chemical (toxic) pneumonitis
I.ao I - Interstitial/parenchymal lung disease
I.ao - Pulmonary infiltrates
II.a II - Pulmonary edema - Acute lung injury - ARDS
II.a - Pulmonary edema, noncardiogenic (NCPE)
II.b II - Pulmonary edema - Acute lung injury - ARDS
II.b - ARDS - Acute lung injury
III.a III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.a - Alveolar hemorrhage (AH), diffuse AH (DAH)
III.j III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.j - Anti-GBM-related pneumorenal syndrome and DAH (Goodpasture) or flare of
IV.j IV - Airway involvement
IV.j - Bronchiolitis (a clinical-imaging pattern suggestive of)
IV.n IV - Airway involvement
IV.n - Obstructive airway dysfunction (see also IVc, XVx)
IV.q IV - Airway involvement
IV.q - Reactive airway dysfunction syndrome (RADS)
IV.aj IV - Airway involvement
IV.aj - Airway hemorrhage on endoscopy
VIII.al VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.al - Epiglottitis
XV.w XV - Pathology
XV.w - Path: Pulmonary edema (see also II/IIa)
XVI.v XVI - Imaging
XVI.v - Imaging: Centrilobular micronodules (can be diffuse)
XVI.ai XVI - Imaging
XVI.ai - Imaging: A 'tree-in-bud' pattern
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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