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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Chlorine gas (dichlorine: Cl2)
5
III.j
Anti-GBM-related pneumorenal syndrome and DAH (Goodpasture) or flare of
1
Last update :
15/06/2019
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
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Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Gases
Halogens
Publications
Provocation of pulmonary haemorrhage in Goodpasture syndrome by chlorine gas.