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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
XXIII.a
Acute respiratory distress
See PMID 30527617
Last update :
01/01/1970
Causative drugs
2
Drug overdose
II.a
II - Pulmonary edema - Acute lung injury - ARDS
II.a - Pulmonary edema, noncardiogenic (NCPE)
IX.d
IX - Neuromuscular / CNS involvement - Disordered breathing during sleep
IX.d - Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)
XI.r
XI - Miscellaneous
XI.r - Death following exposure or poisoning
XII.e
XII - Cardiovascular involvement / toxicity
XII.e - Takotsubo (stress) cardiomyopathy
XXIII.a
XXIII - Issues during mechanical ventilation
XXIII.a - Acute respiratory distress
5
Mechanical ventilation (invasive)
V.f
V - Pleural and/or pericardial involvement
V.f - Pneumothorax
VII.h
VII - Mediastinal involvement
VII.h - Pneumomediastinum
XI.ae
XI - Miscellaneous
XI.ae - Barotrauma (incl. pneumothorax, pneumomediastinum, interstitial ephysema...)
XVI.af
XVI - Imaging
XVI.af - Imaging: Lung cysts or bullae (see also XVI ah/bf)
XXIII.a
XXIII - Issues during mechanical ventilation
XXIII.a - Acute respiratory distress
2
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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