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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
IX.z
Hypocalcemia (may lead to respiratory muscle weakness and RF)
See also under IX&
Last update :
01/01/1970
Causative drugs
1
Denosumab
I.b
I - Interstitial/parenchymal lung disease
I.b - Pneumonitis (ILD)
I.ao
I - Interstitial/parenchymal lung disease
I.ao - Pulmonary infiltrates
VIII.a
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.a - Angioedema (may cause UAO, asphyxia and death)
VIII.ad
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.ad - Osteonecrosis of the jaw
IX.h
IX - Neuromuscular / CNS involvement - Disordered breathing during sleep
IX.h - Dyspnea, unexplained otherwise
IX.z
IX - Neuromuscular / CNS involvement - Disordered breathing during sleep
IX.z - Hypocalcemia (may lead to respiratory muscle weakness and RF)
X.s
X - Systemic/Distant conditions, syndromes and reactions
X.s - Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive
1
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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