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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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IX.z

Hypocalcemia (may lead to respiratory muscle weakness and RF)

See also under IX&

Last update : 01/01/1970
 

Causative drugs

1

Denosumab

I.b I - Interstitial/parenchymal lung disease
I.b - Pneumonitis (ILD)
I.ao I - Interstitial/parenchymal lung disease
I.ao - Pulmonary infiltrates
VIII.a VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.a - Angioedema (may cause UAO, asphyxia and death)
VIII.ad VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.ad - Osteonecrosis of the jaw
IX.h IX - Neuromuscular / CNS involvement - Disordered breathing during sleep
IX.h - Dyspnea, unexplained otherwise
IX.z IX - Neuromuscular / CNS involvement - Disordered breathing during sleep
IX.z - Hypocalcemia (may lead to respiratory muscle weakness and RF)
X.s X - Systemic/Distant conditions, syndromes and reactions
X.s - Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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