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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Dapsone (diaminophenylsulfone)

4

X.a DRES syndrome - DRESS-like reaction

1
Last update : 08/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Pyrimethamine-dapsone
1

Publications

Dapsone hypersensitivity syndrome-related lung injury without eosinophilia in the bronchoalveolar lavage fluid.
Internal medicine (Tokyo, Japan) 2015;54;827-31 2015
Severe dapsone hypersensitivity syndrome in a child.
Korean journal of pediatrics 2013 Jun;56;260-4 2013 Jun
Dapsone hypersensitivity syndrome among leprosy patients in China.
Leprosy review 2012 Dec;83;370-7 2012 Dec
Dapsone Hypersensitivity Syndrome That Occurred during Treatment of Pediatric Patient with Erythema Elevatum Diutinum.
Annals of dermatology 2011 Dec;23;S290-5 2011 Dec
[Rash, fever, eosinophilia and elevated liver enzymes. DRESS syndrome (drug reaction or rash with eosinophilia and systemic symptoms)].
Praxis 2010 Jun 23;99;767-77; quiz 776 2010 Jun 23
Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases.
Archives of dermatology 2010 Dec;146;1373-9 2010 Dec
The Dapsone hypersensitivity syndrome revisited: a potentially fatal multisystem disorder with prominent hepatopulmonary manifestations.
Journal of occupational medicine and toxicology (London, England) 2006 Jun 06;1;9 2006 Jun 06

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