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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Levamisole-adulterated/tainted cocaine

5

X.ak Dual MPO-/PR3-ANCA systemic disease/vasculitis/pseudovasculitis

1
Last update : 19/09/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Abused drugs/substances (illicit-, street drugs - IV/inhaled)
5
Aminorex
5
Cocaine
5
Crack cocaine
5
Levamisole
4

Publications

Unusual case of levamisole-induced dual-positive ANCA vasculitis and crescentic glomerulonephritis.
BMJ case reports 2018 Sep 19;2018; 2018 Sep 19
Cocaine and ANCA associated vasculitis-like syndromes - A case series.
Autoimmunity reviews 2018 Jan;17;73-77 2018 Jan
Cocaine/levamisole-associated autoimmune syndrome: a disease of neutrophil-mediated autoimmunity.
Current opinion in hematology 2018 Jan;25;29-36 2018 Jan
A Case Report on Suspected Levamisole-Induced Pseudovasculitis.
WMJ : official publication of the State Medical Society of Wisconsin 2017 Feb;116;37-9 2017 Feb
Cocaine/levamisole-induced systemic vasculitis with retiform purpura and pauci-immune glomerulonephritis.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2016;49;e5244 2016
Levamisole-contaminated cocaine: a hairy affair.
BMJ case reports 2015 Aug 26;2015; 2015 Aug 26
Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.
Current opinion in rheumatology 2014 Jan;26;42-9 2014 Jan

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