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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Levamisole-adulterated/tainted cocaine

5

X.ad Skin purpura, ecchymoses or necrosis

3
Last update : 30/04/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Abused drugs/substances (illicit-, street drugs - IV/inhaled)
5
Aminorex
5
Cocaine
5
Crack cocaine
5
Levamisole
4

Publications

A Case Report on Suspected Levamisole-Induced Pseudovasculitis.
WMJ : official publication of the State Medical Society of Wisconsin 2017 Feb;116;37-9 2017 Feb
Levamisole-Induced Vasculitis: A Characteristic Cutaneous Vasculitis Associated With Levamisole-Adulterated Cocaine.
Archives of pathology & laboratory medicine 2015 Aug;139;1058-61 2015 Aug
Levamisole-adulterated cocaine induced skin necrosis of nose, ears, and extremities: Case report.
Allergy & rhinology (Providence, R.I.) 2014 Jan;5;132-6 2014 Jan
Levamisole-contaminated cocaine: an emergent cause of vasculitis and skin necrosis.
Case reports in medicine 2014;2014;434717 2014
Photoletter to the editor: Diffuse cocaine-related purpura.
Journal of dermatological case reports 2013;7;132-3 2013
Levamisole induced necrosis of the skin and neutropenia following intranasal cocaine use: a newly recognized syndrome.
Journal of drugs in dermatology : JDD 2011 Oct;10;1204-7 2011 Oct
Levamisole-induced thrombosis: literature review and pertinent laboratory findings.
Journal of the American Academy of Dermatology 2011 Oct;65;e128-e129 2011 Oct
Cocaine-related retiform purpura: evidence to incriminate the adulterant, levamisole.
Journal of cutaneous pathology 2010 Dec;37;1212-9 2010 Dec

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