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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Levamisole-adulterated/tainted cocaine

5

X.s Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

3

Pathophysiology at PMID 27354687

Last update : 04/01/2019
 
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Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Abused drugs/substances (illicit-, street drugs - IV/inhaled)
5
Aminorex
5
Cocaine
5
Crack cocaine
5
Levamisole
4

Publications

[Cocaine-induced vasculitis and mimics of vasculitis].
Zeitschrift fur Rheumatologie 2023 Sep;82;606-614 2023 Sep
Pulmonary-Renal Syndrome from Levamisole-Adulterated Cocaine-Induced Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis: A Systematic Review.
Pharmaceuticals (Basel, Switzerland) 2023 Jun 06;16; 2023 Jun 06
Multiple cutaneous and mucosal lesions in a patient with cocaine-levamisole-induced vasculopathy syndrome.
Proceedings (Baylor University. Medical Center) 2019 Jan;32;93-95 2019 Jan
Clinical Profile of Levamisole-Adulterated Cocaine-Induced Vasculitis/Vasculopathy: A 30-Case Series.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2019 Apr;25;e16-e26 2019 Apr
Unusual case of levamisole-induced dual-positive ANCA vasculitis and crescentic glomerulonephritis.
BMJ case reports 2018 Sep 19;2018; 2018 Sep 19
Levamisole-induced vasculopathy with gastric involvement in a cocaine user.
Cutis 2018 Sep;102;169;170;175;176 2018 Sep
Cocaine and ANCA associated vasculitis-like syndromes - A case series.
Autoimmunity reviews 2018 Jan;17;73-77 2018 Jan
Levamisole adulterated cocaine associated ANCA vasculitis: review of literature and update on pathogenesis.
Journal of community hospital internal medicine perspectives 2018;8;339-344 2018
Cocaine-Levamisole-Induced Vasculitis/Vasculopathy Syndrome.
Current rheumatology reports 2017 Jun;19;36 2017 Jun
A Case Report on Suspected Levamisole-Induced Pseudovasculitis.
WMJ : official publication of the State Medical Society of Wisconsin 2017 Feb;116;37-9 2017 Feb
ANCA Associated Vasculitis Secondary to Levamisole-Adultered Cocaine with Associated Membranous Nephropathy: A Case Series.
American journal of nephrology 2017;45;209-216 2017
Cocaine induced pleural and pericardial effusion syndrome.
Case reports in pulmonology 2015;2015;321539 2015
Levamisole/Cocaine Induced Systemic Vasculitis and Immune Complex Glomerulonephritis.
Case reports in nephrology 2015;2015;372413 2015
Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.
Current opinion in rheumatology 2014 Jan;26;42-9 2014 Jan
Photoletter to the editor: Diffuse cocaine-related purpura.
Journal of dermatological case reports 2013;7;132-3 2013

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