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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Cyclophosphamide

4

XVII.e Pneumocystis jiroveci pneumonia

1
Last update : 30/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Alkylating agents
5
Cyclophosphamide (i.v infusional)
2

Publications

A case of granulomatosis with polyangiitis complicated by cyclophosphamide toxicity and opportunistic infections: choosing between Scylla and Charybdis.
BMC nephrology 2014 Feb 04;15;28 2014 Feb 04
Pulmonary complications of combination therapy with cyclophosphamide and prednisone.
Chest 1991 Jan;99;143-6 1991 Jan
Post-cyclophosphamide pneumonitis.
The New England journal of medicine 1972 Sep 28;287;668-9 1972 Sep 28

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