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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Cyclophosphamide

4

XII.f Cardiomyopathy (acute, subacute, chronic)

1
Last update : 15/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
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Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Alkylating agents
5
Cyclophosphamide (i.v infusional)
2

Publications

Cardiotoxicity following cyclophosphamidetherapy: a case report.
Journal of medical case reports 2014 Jul 14;8;252 2014 Jul 14
Cyclophosphamide-associated cardiotoxicity in a child after stem cell transplantation for β-thalassemia major: case report and review of the literature.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2014;17;50-4 2014
Irreversible end-stage cardiomyopathy following a single dose of cyclophosphamide.
Congestive heart failure (Greenwich, Conn.) 2012;18;234-7 2012
Cardiomyopathy following intravenous cyclophosphamide therapy in a patient with Wegener's granulomatosis.
Clinical and experimental rheumatology 1996;14;702-3 1996
Cyclophosphamide-induced cardiomyopathy: a report of two cases and review of the English literature.
Cancer 1979 Jun;43;2223-6 1979 Jun
Cardiac and pulmonary effects of high doses of cyclophosphamide and isophosphamide.
Cancer research 1974 Jul;34;1586-91 1974 Jul

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