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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Cyclophosphamide

4

II.b ARDS - Acute lung injury

2
Last update : 10/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Alkylating agents
5
Cyclophosphamide (i.v infusional)
2

Publications

Acute respiratory failure during first cyclophosphamide infusion in a patient with systemic lupus erythematosus.
Zeitschrift fur Rheumatologie 2014 Dec;73;939-41 2014 Dec
Cyclophosphamide-induced acute respiratory distress syndrome.
Respirology (Carlton, Vic.) 2007 Sep;12;769-73 2007 Sep
Cyclophosphamide in combination with sargramostim for treatment of recurrent medulloblastoma.
Medical and pediatric oncology 1995 Sep;25;190-6 1995 Sep
Interstitial pneumonia after prolonged treatment with cyclophosphamide.
The American review of respiratory disease 1973 Jul;108;114-7 1973 Jul

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