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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Cyclophosphamide

4

V.c Pleural thickening - Fibrothorax

2
Last update : 18/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Alkylating agents
5
Cyclophosphamide (i.v infusional)
2

Publications

Acquired Platythorax, or Anteroposterior Flattening of the Chest Wall, as a Late Complication of Cyclophosphamide Treatment for Childhood Acute Lymphoblastic Leukemia, Presenting in a Young Man with Respiratory Failure.
The American journal of case reports 2018 Nov 05;19;1317-1323 2018 Nov 05
Pleuroparenchymal fibroelastosis in patients with pulmonary disease secondary to bone marrow transplantation.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011 Dec;24;1633-9 2011 Dec
Cyclophosphamide-induced late-onset lung disease.
Internal medicine (Tokyo, Japan) 2003 Jan;42;82-7 2003 Jan
Lung toxicity associated with cyclophosphamide use. Two distinct patterns.
American journal of respiratory and critical care medicine 1996 Dec;154;1851-6 1996 Dec
Lung transplantation for chemotherapy-induced pulmonary fibrosis.
Chest 1994 Jan;105;310-2 1994 Jan
Progressive pulmonary fibrosis complicating cyclophosphamide therapy.
Acta medica Scandinavica 1987;221;403-7 1987

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