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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Selective serotonin reuptake inhibitors (SSRI)- Serotonergic drugs
2
VI.b
Pulmonary arterial hypertension
2
Last update :
10/06/2013
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Antidepressants
Clomipramine
Duloxetine
Fluoxetine
Olanzapine
Paroxetine
Sertraline
Venlafaxine
Publications
Selective serotonin reuptake inhibitors and pulmonary arterial hypertension: a case-control study.
Antidepressant medication use and risk of persistent pulmonary hypertension of the newborn.
