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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Clozapine

3

VI.a Pulmonary embolism - Venous thrombosis/thromboembolism

3
Last update : 09/08/2012
 
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Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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See also under
Antidepressants
3

Publications

Clozapine-Associated Pulmonary Embolism: A High-Mortality, Dose-Independent and Early-Onset Adverse Effect.
American journal of therapeutics 2018;25;e434-e438 2018
Clozapine-induced recurrent pulmonary thromboembolism.
The Journal of neuropsychiatry and clinical neurosciences 2013;25;E50-1 2013
A case of cardiac arrest and pulmonary embolism after clozapine titration.
The primary care companion for CNS disorders 2011;13; 2011
Nonfatal pulmonary embolus associated with clozapine treatment: a case series.
General hospital psychiatry 2011;33;85.e5-6 2011
Pulmonary embolism in a patient taking clozapine.
BMJ (Clinical research ed.) 2008 Jun 28;336;1499-501 2008 Jun 28
Massive pulmonary embolism in a young patient on clozapine therapy.
The Journal of emergency medicine 2004 Jul;27;27-9 2004 Jul
Clozapine and pulmonary embolism.
Acta psychiatrica Scandinavica 2003 Jul;108;76-7; discussion 77 2003 Jul
Clozapine therapy and pulmonary embolism.
Canadian journal of psychiatry. Revue canadienne de psychiatrie 2000 May;45;395 2000 May
Association of venous thromboembolism and clozapine.
Lancet (London, England) 2000 Apr 01;355;1155-6 2000 Apr 01
[Clozapine and myocarditis].
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 1995 Oct 10;115;3026-7 1995 Oct 10

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