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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Clozapine

3

XI.n Neutropenia, agranulocytosis (w/wo infection/sepsis)

2
Last update : 09/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Antidepressants
3

Publications

Clozapine-associated pneumonia and respiratory arrest secondary to severe constipation.
Medicine, science, and the law 2014 Apr;54;105-9 2014 Apr
Clozapine-induced agranulocytosis. Incidence and risk factors in the United States.
The New England journal of medicine 1993 Jul 15;329;162-7 1993 Jul 15

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