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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Clozapine

3

XII.d Myocarditis (can be fulminant)

5
Last update : 17/04/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Antidepressants
3

Publications

Successful clozapine rechallenge after myopericarditis: a case report.
International clinical psychopharmacology 2022 Jul 01;37;179-181 2022 Jul 01
40-Year-Old Man With Fatigue, Dyspnea, and Nausea.
Mayo Clinic proceedings 2019 Jan;94;e1-e6 2019 Jan
Clozapine-Induced Cardiotoxicity Presenting as Sepsis: A Case Report and Literature Review.
Case reports in medicine 2019;2019;3435108 2019
Five Cases of Clozapine-Associated Cardiotoxicity and Implications for Monitoring.
Psychosomatics 2019;60;524-527 2019
Intravenous Immunoglobulin and Methylprednisolone for Clozapine-Associated Perimyocarditis.
American journal of therapeutics 2019;26;e485-e486 2019
Potentially fatal outcomes associated with clozapine.
Schizophrenia research 2018 Sep;199;386-389 2018 Sep
Clozapine-induced myocarditis may be associated with rapid titration: A case report verified with autopsy.
International journal of psychiatry in medicine 2016;51;104-15 2016
Clozapine-induced myocarditis, a widely overlooked adverse reaction.
Acta psychiatrica Scandinavica 2015 Oct;132;231-40 2015 Oct
A Case of Clozapine-Induced Myocarditis in a Young Patient with Bipolar Disorder.
Case reports in cardiology 2015;2015;283156 2015
Update on the adverse effects of clozapine: focus on myocarditis.
Current drug safety 2012 Feb;7;55-62 2012 Feb
A new monitoring protocol for clozapine-induced myocarditis based on an analysis of 75 cases and 94 controls.
The Australian and New Zealand journal of psychiatry 2011 Jun;45;458-65 2011 Jun
Clozapine-associated myocarditis: a review of 116 cases of suspected myocarditis associated with the use of clozapine in Australia during 1993-2003.
Drug safety 2007;30;47-57 2007
Clozapine-induced hypersensitivity myocarditis.
Chest 2004 Nov;126;1703-5 2004 Nov

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