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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Clozapine
3
V.m
Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
2
Last update :
09/08/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Antidepressants
Publications
Clozapine-associated severe eosinophilia following lithium rebound neutropenia: A case report.
Late occurrence of clozapine-associated polyserositis.
[Malignant neuroleptic syndrome and polyserositis associated to clozapine use: report of one case].
Clozapine-induced pericarditis, pericardial tamponade, polyserositis, and rash.
Pericardial and bilateral pleural effusion associated with clozapine treatment.
Pericarditis and polyserositis as a side effect of clozapine in an adolescent girl.
Clozapine-associated polyserositis.
Sweet's syndrome and polyserositis with clozapine.
Polyserositis, acute withdrawal, and relapse after abrupt clozapine discontinuation.
Clozapine induced polyserositis.
Polyserositis associated with clozapine treatment.
