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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Dexfenfluramine
3
VI.b
Pulmonary arterial hypertension
1
Last update :
26/01/2013
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Aminorex
Amphetamine (and -derivatives)
Cocaine
Fenfluramine
Levamisole
Publications
Pulmonary arterial hypertension in a patient with Cowden syndrome and anorexigen exposure.
Benfluorex and unexplained valvular heart disease: a case-control study.
Fenfluramine-like cardiovascular side-effects of benfluorex.
Aminorex, dexfenfluramine, and primary pulmonary hypertension.
Pulmonary hypertension and dexfenfluramine.