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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Dexfenfluramine

3

VI.b Pulmonary arterial hypertension

1
Last update : 26/01/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Aminorex
5
Amphetamine (and -derivatives)
3
Cocaine
5
Fenfluramine
3
Levamisole
4

Publications

Pulmonary arterial hypertension in a patient with Cowden syndrome and anorexigen exposure.
Chest 2011 Oct;140;1066-1068 2011 Oct
Benfluorex and unexplained valvular heart disease: a case-control study.
PloS one 2010 Apr 12;5;e10128 2010 Apr 12
Fenfluramine-like cardiovascular side-effects of benfluorex.
The European respiratory journal 2009 Mar;33;684-8 2009 Mar
Aminorex, dexfenfluramine, and primary pulmonary hypertension.
Journal of clinical epidemiology 1998 Apr;51;361-4 1998 Apr
Pulmonary hypertension and dexfenfluramine.
Lancet (London, England) 1992 Feb 15;339;436 1992 Feb 15

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