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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Chlorpropamide

1

X.a DRES syndrome - DRESS-like reaction

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Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Chlorpropamide-induced pulmonary infiltration and eosinophilia with multisystem toxicity.
Journal of the Tennessee Medical Association 1986 Feb;79;82-4 1986 Feb
Severe chlorpropamide toxicity.
Journal of the American Medical Association 1960 Jan 02;172;54-6 1960 Jan 02

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