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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Baclofen

2

IX.p Disordered breathing during sleep - Sleep apnea

1
Last update : 28/02/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Baclofen withdrawal
1

Publications

Baclofen and sleep apnoea syndrome: analysis of VigiBase, the WHO pharmacovigilance database.
The European respiratory journal 2018 Jan;51; 2018 Jan
Baclofen-Associated Onset of Central Sleep Apnea in Alcohol Use Disorder: A Case Report.
Respiration; international review of thoracic diseases 2015;90;507-511 2015
Pilot study assessing the impact of intrathecal baclofen administration mode on sleep-related respiratory parameters.
Archives of physical medicine and rehabilitation 2012 Jan;93;96-9 2012 Jan

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