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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Baclofen withdrawal
1
Last update :
04/01/2017
II - Pulmonary edema - Acute lung injury - ARDS
II.q
Respiratory distress or failure, not otherwise specified
1
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.c
Upper airway obstruction other than angioedema or hematoma
1
VIII.e
Laryngospasm (a.k.a. laryngismus)
1
VIII.h
Vocal cord dysfunction, adduction, closure, injury
1
IX - Neuromuscular / CNS involvement - Disordered breathing during sleep
IX.c
Chest wall muscle rigidity - Stiff/wooden chest
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Baclofen
