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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Neuroleptics - Antipsychotics

4

II.b ARDS - Acute lung injury

2
Last update : 16/10/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Chlorpromazine
2
Clozapine
3
Flupentixol
1
Haloperidol
1
Risperidone
1
Zolpidem
1

Publications

Neuroleptic-induced acute respiratory distress syndrome.
Sao Paulo medical journal = Revista paulista de medicina 2003 May 05;121;121-4 2003 May 05
Diffuse alveolar damage and recurrent respiratory failure: report of 6 cases.
Human pathology 2001 Dec;32;1398-402 2001 Dec
Adult respiratory distress syndrome from overdose of tricyclic antidepressants.
Radiology 1989 Mar;170;667-70 1989 Mar
Neuroleptic malignant syndrome presenting as adult respiratory distress syndrome and disseminated intravascular coagulation.
Southern medical journal 1988 Apr;81;543-5 1988 Apr

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